Telomeres and Their Neighbors

0561829 - BFÚ 2023 RIV CH eng J - Článek v odborném periodiku
Jenner, Leon - Peška, Vratislav - Fulnečková, Jana - Sýkorová, Eva
Telomeres and Their Neighbors.
Genes. Roč. 13, č. 9 (2022), č. článku 1663. E-ISSN 2073-4425
Grant CEP: GA ČR(CZ) GX20-01331X; GA ČR(CZ) GA19-12607S; GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: satellite * telomere evolution * interstitial telomere sequences * retroelements * subtelomere structure * telomerase RNA * trap
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 3.5, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2073-4425/13/9/1663

Telomeres are essential structures formed from satellite DNA repeats at the ends of chromosomes in most eukaryotes. Satellite DNA repeat sequences are useful markers for karyotyping, but have a more enigmatic role in the eukaryotic cell. Much work has been done to investigate the structure and arrangement of repetitive DNA elements in classical models with implications for species evolution. Still more is needed until there is a complete picture of the biological function of DNA satellite sequences, particularly when considering non-model organisms. Celebrating Gregor Mendel's anniversary by going to the roots, this review is designed to inspire and aid new research into telomeres and satellites with a particular focus on non-model organisms and accessible experimental and in silico methods that do not require specialized equipment or expensive materials. We describe how to identify telomere (and satellite) repeats giving many examples of published (and some unpublished) data from these techniques to illustrate the principles behind the experiments. We also present advice on how to perform and analyse such experiments, including details of common pitfalls. Our examples are a selection of recent developments and underexplored areas of research from the past. As a nod to Mendel's early work, we use many examples from plants and insects, especially as much recent work has expanded beyond the human and yeast models traditional in telomere research. We give a general introduction to the accepted knowledge of telomere and satellite systems and include references to specialized reviews for the interested reader.
Trvalý link: https://hdl.handle.net/11104/0340718