Obeticholic acid forms two series of isostructural non-stoichiometric channel solvates

0561353 - FZÚ 2023 RIV US eng J - Článek v odborném periodiku
Skořepová, Eliška - Václavík, M. - Jirát, J. - Poupon, Morgane - Ridvan, L. - Babor, M. - Šoóš, M.
Obeticholic acid forms two series of isostructural non-stoichiometric channel solvates.
Crystal Growth & Design. Roč. 22, č. 9 (2022), s. 5589-5597. ISSN 1528-7483. E-ISSN 1528-7505
Grant CEP: GA MŠMT(CZ) EF16_019/0000760; GA ČR(CZ) GJ20-14770Y
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: crystal structure * molecules * organic compounds * solvates * solvents * X-ray diffraction
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.8, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1021/acs.cgd.2c00688

The aim of this work was to investigate solid forms of an active pharmaceutical substance, obeticholic acid, and to characterize the discovered structures. Obeticholic acid is used to treat primary biliary cholangitis. No crystal structures have been published until now. Our X-ray powder diffraction results revealed that upon crystallization from various solvents, obeticholic acid forms one of two possible forms. Further investigation by thermogravimetric analysis and differential scanning calorimetry showed that the two forms are in fact solvated.
Trvalý link: https://hdl.handle.net/11104/0334020