Elements´bioaccessibility and oxidative of urban aerosol in three simulated lung flusids

0560468 - ÚIACH 2023 CZ eng A - Abstrakt
Cigánková, Hana - Mikuška, Pavel
Elements´bioaccessibility and oxidative of urban aerosol in three simulated lung flusids.
Czech Chemical Society Symposium Series. "Amerika" 21st, č. 20 (2022), s. 9-9. ISSN 2336-7202.
[Mezioborové setkání mladých biologů, biochemiků a chemiků /21./. 16.05.2022-19.05.2022, Milovy]
Grant CEP: GA ČR(CZ) GA20-02203S
Institucionální podpora: RVO:68081715
Klíčová slova: urban aerosol * bioaccessibility * oxidative potential
Obor OECD: Analytical chemistry

The aim of this work was to determine the bioaccessibility of 21 elements bound to PM1 and PM2.5 urban aerosol and OP of both studied aerosol size fractions in three simulated lung fluids: deionised water, simulated alveoli fluid (SAF) and Gamble’s solution. It was found that the bioaccessibility of elements depends on their chemical compound, aerosol size fraction and the chemical composition of the SLF.
The OP of urban PM was studied as a relevant metric for health effects using the dithiothreitol assay. The difference of OP value in deionised water to SAF and Gamble’s solution indicated the crucial effect of individual SLFs’ chemical composition on the OP. The complexation of the elements with different ligands present in the solution can influence OP and, therefore, the potential health effects of inhaled aerosol.
Trvalý link: https://hdl.handle.net/11104/0333391