Ultrafine particles and their possible role in etiology and development of neurodegenerative diseases

0560378 - ÚEM 2023 RIV CZ eng K - Konferenční příspěvek (tuzemská konf.)
Topinka, Jan - Závodná, Táňa - Rössnerová, Andrea - Rössner ml., Pavel
Ultrafine particles and their possible role in etiology and development of neurodegenerative diseases.
Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./. Ostrava: Tanger Ltd., 2020 - (Shrbená-Váňová, J.), s. 705-709. ISBN 978-80-87294-95-6.
[International Conference on Nanomaterials - Research and Application, NANOCON 2019 /11./. Brno (CZ), 16.10.2019-18.10.2019]
Grant CEP: GA MŠMT(CZ) LM2015073; GA MŠMT(CZ) LO1508
Institucionální podpora: RVO:68378041
Klíčová slova: Alzheimer's disease * inflammation * neurodegenerative diseases * ultrafine particles
Obor OECD: Occupational health
https://dx.doi.org/10.37904/nanocon.2019.8558

Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, chronic obstructive pulmonary disease) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer's disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. Our new H2020 project TUBE aims on revealing the mechanisms of action of ultrafine particles involved in neurological diseases. The TUBE consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. We will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming to a comprehensive understanding of the adverse brain effects of nanoparticles from traffic.
Trvalý link: https://hdl.handle.net/11104/0341292