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Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms
- 1.0560073 - FZÚ 2023 RIV GB eng J - Článek v odborném periodiku
Jirát, J. - Babor, M. - Ridvan, L. - Skořepová, Eliška - Dušek, Michal - Šoóš, M.
Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms.
IUCrJ. Roč. 9, č. 4 (2022), s. 508-515. ISSN 2052-2525. E-ISSN 2052-2525
Institucionální podpora: RVO:68378271
Klíčová slova: apremilast * structure-property relations * multicomponent forms * equilibrium solubility * bioavailability
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.9, rok: 2022
Způsob publikování: Open access
The structure–property relations are examined for apremilast cocrystals and solvates in this work. A unique and large dataset of multicomponent crystal forms is presented including 7 cocrystals and 12 solvates. In total, 15 of the presented multicomponent forms and their crystal structures are published here for the first time. This dataset is unique owing to the extreme crystal packing similarity of all 19 crystal forms. This fact makes the evaluation of structure–property relations significantly easier and more precise since the differences in the crystal lattice arrangement are close to negligible.
Trvalý link: https://hdl.handle.net/11104/0333623
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