The analysis of differential expression and interactions of host and virus derived RNAs in human primary neural cells reveals candidate effectors of TBEV-induced neuropathogenesis

0560032 - BC 2023 RIV GB eng A - Abstrakt
Selinger, Martin - Věchtová, Pavlína - Tykalová, T. - Oslejskova, P. - Rumlová, M. - Štěrba, J. - Grubhoffer, Libor
The analysis of differential expression and interactions of host and virus derived RNAs in human primary neural cells reveals candidate effectors of TBEV-induced neuropathogenesis.
FEBS Open Bio. Wiley. Roč. 12, Supl. 1 (2022), s. 164-165. ISSN 2211-5463. E-ISSN 2211-5463
Institucionální podpora: RVO:60077344
Klíčová slova: analysis * expression * RNAs
Obor OECD: Biochemistry and molecular biology

Arthropod-borne pathogens have been gaining major attentionof medical research with spreading distribution of their vectors inresponse to changing climate. The incidence of tick borne-en-cephalitis virus (TBEV), often causing severe neurological symp-toms in humans, has also been increasing despite the existence ofvaccines. Effective treatment and symptom alleviation of patientsrequire a thorough knowledge of TBEV-induced neuropathogen-esis, which has not been accomplished to date
Trvalý link: https://hdl.handle.net/11104/0340281