Independent somatic distribution of heme and iron in ticks

0560031 - BC 2023 RIV NL eng J - Článek v odborném periodiku
Perner, Jan - Hajdušek, Ondřej - Kopáček, Petr
Independent somatic distribution of heme and iron in ticks.
Current Opinion in Insect Science. Roč. 51, JUN (2022), č. článku 100916. ISSN 2214-5745. E-ISSN 2214-5753
Grant CEP: GA ČR(CZ) GA21-08826S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GM22-18424M
Institucionální podpora: RVO:60077344
Klíčová slova: Ticks * ectoparasites * metabolic cofactor
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 5.3, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S2214574522000517?via%3Dihub

Ticks are blood-feeding ectoparasites with distinct genomic reductions, inevitably linking them to a parasitic lifestyle. Ticks have lost the genomic coding and, thus, biochemical capacity to synthesize heme, an essential metabolic cofactor, de novo. Instead, they are equipped with acquisition and distribution pathways for reuse of host heme. Unlike insects or mammals, ticks and mites cannot cleave the porphyrin ring of heme to release iron. Bioavailable iron is thus acquired by ticks from the host serum transferrin. Somatic trafficking of iron, however, is independent of heme and is mediated by a secretory type of ferritin. Heme and iron systemic homeostasis in ticks represents, therefore, key adaptive traits enabling successful feeding and reproduction.
Trvalý link: https://hdl.handle.net/11104/0340178