Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

0559906 - ÚMG 2023 RIV GB eng J - Článek v odborném periodiku
Rubbiani, R. - Wu, W. - Naik, A. - Larocca, M. - Schneider, L. - Padrutt, R. - Babu, V. - König, C. - Hinger, D. - Maake, C. - Ferrari, Stefano - Gasser, G. - Spingler, B.
Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling.
Chemical Communications. Roč. 56, č. 92 (2020), s. 14373-14376. ISSN 1359-7345. E-ISSN 1364-548X
Institucionální podpora: RVO:68378050
Klíčová slova: Single crystal growth * nano crystallization * DNA * Cancer * Transplatin * Generation * Complexes * Toxicity * Agents * Cisplatin
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 6.222, rok: 2020
Způsob publikování: Open access
https://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC05196A

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, Zn-67 isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
Trvalý link: https://hdl.handle.net/11104/0333031