Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses

0559903 - ÚOCHB 2023 RIV eng P - Patentový dokument
Veselovská, Lucia - Hocek, Michal - Hajdúch, M. - Džubák, P.
Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses.
2022. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Datum udělení patentu: 12.04.2022. Číslo patentu: US11299510
Grant CEP: GA ČR(CZ) GA16-00178S; GA TA ČR(CZ) TE01020028; GA MZd(CZ) NV15-31984A; GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: nucleosides * fused heterocycles * cytostatics
Obor OECD: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/065763222/publication/US11299510B2?q=US11299510B2

Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.
Trvalý link: https://hdl.handle.net/11104/0333030