DNA interaction and BSA binding of O-vanillin-based new Schiff base Co (III) and Ni(II) complexes: Theoretical, experimental, antibacterial and anticancer studies

0559840 - FZÚ 2023 RIV GB eng J - Článek v odborném periodiku
Keshavarzian, E. - Asadi, Z. - Kučeráková, Monika - Dušek, Michal - Rastegari, B.
DNA interaction and BSA binding of O-vanillin-based new Schiff base Co (III) and Ni(II) complexes: Theoretical, experimental, antibacterial and anticancer studies.
Polyhedron. Roč. 223, Sep (2022), č. článku 115987. ISSN 0277-5387. E-ISSN 1873-3719
Grant CEP: GA ČR(CZ) GA18-10504S
Výzkumná infrastruktura: CzechNanoLab - 90110
Institucionální podpora: RVO:68378271
Klíčová slova: Ni^II schiff base complex * Co^III schiff base complex * DNA & BSA binding * molecular docking * fow cytometry * crystal structure
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 2.6, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.poly.2022.115987

In the present work, two new mononuclear CoIII and NiII complexes containing H2valmea Schiff base ligand (H2valmea = 2-(((2-hydroxyethyl)imino)methyl)-6-methoxyphenol) were synthesized. X-ray crystallography, besides other techniques such as CHN, FT-IR and UV–Vis spectroscopy, determined the exact structures of both complexes. Bio-interactions (BSA and DNA binding), the antineoplastic ability and basal cell toxicity of complexes were investigated by various experimental and docking methods. Fluorescence emission and UV–Vis absorbance experiments confirmed the static mechanism in the interaction of both complexes with protein.
Trvalý link: https://hdl.handle.net/11104/0333622