Covalent functionalization of Ti.sub.3./sub.C.sub.2./sub.T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent

0557728 - FZÚ 2023 RIV NL eng J - Článek v odborném periodiku
Neubertová, V. - Guselnikova, O. - Yamauchi, Y. - Olshtrem, A. - Rimpelová, S. - Čižmár, E. - Orendáč, M. - Duchoň, Jan - Volfová, Lenka - Lančok, Ján - Herynek, V. - Fitl, P. - Ulbrich, P. - Jelínek, L. - Schneider, P. - Kosek, J. - Postnikov, P. - Kolská, Z. - Švorčík, V. - Chertopalov, Sergii - Lyutakov, O.
Covalent functionalization of Ti₃C₂T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent.
Chemical Engineering Journal. Roč. 446, č. 2 (2022), č. článku 136939. ISSN 1385-8947. E-ISSN 1873-3212
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Výzkumná infrastruktura: CzechNanoLab - 90110
Institucionální podpora: RVO:68378271
Klíčová slova: MXene * surface chemistry * covalent functionalization * magnetic properties * MRI contrast agents * stability in bioliquids * cytotoxicity
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 15.1, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.cej.2022.136939

MXenes are an excellent candidate for medical applications, including diagnostic approaches such as positron emission tomography, computed tomography, and magnetic resonance imaging (MRI). However, the utilization of MXenes for bioimaging is restricted by their commonly diamagnetic nature. MXenes can be functionalized using ferromagnetic or paramagnetic compounds and nanoparticles to develop efficient bioimaging tools. In contrast to previously published approaches based on electrostatic interactions, covalent approaches could enhance MXene stability and prevent self-aggregation with degradation.
Trvalý link: http://hdl.handle.net/11104/0331656