Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options

0556628 - MBÚ 2023 RIV CH eng J - Článek v odborném periodiku
Hrnčíř, Tomáš
Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options.
Microorganisms. Roč. 10, č. 3 (2022), č. článku 578. E-ISSN 2076-2607
Grant CEP: GA ČR(CZ) GA20-09732S; GA ČR(CZ) GA22-12533S
Institucionální podpora: RVO:61388971
Klíčová slova: sulfate-reducing bacteria * intestinal microbiota * ulcerative-colitis * insulin-resistance * diabetes-mellitus * obeticholic acid * transplantation * severity * disease * phosphatidylcholine
Obor OECD: Microbiology
Impakt faktor: 4.5, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2076-2607/10/3/578

The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing. The increased morbidity of human populations makes them more vulnerable to additional burdens, including infectious diseases. For example, the mortality rate of diabetics infected with the original variant of the SARS Co-2 virus was about twice that of the general population. It is becoming increasingly clear that the gut microbiota plays an important role in the development of many, if not all, of these diseases. Many of these diseases, including COVID-19 infection, are associated with alterations in the composition and function of the gut microbiota, i.e., dysbiosis. The focus of this special issue was on all possible triggers of gut microbiota dysbiosis and on exploring ways to restore the gut microbiota, such as nutritional interventions, probiotics, and FMT, to identify disease-associated microbiota signatures, elucidate pathogenetic mechanisms, find new diagnostic and prognostic markers, and develop new microbiota-based treatments
Trvalý link: http://hdl.handle.net/11104/0331296