Počet záznamů: 1
Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases
- 1.0556564 - ÚOCHB 2023 RIV AE eng J - Článek v odborném periodiku
Toman, D. - Jorda, R. - Ajani, Haresh - Kryštof, V. - Cankař, P.
Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases.
Medicinal Chemistry. Roč. 18, č. 4 (2022), s. 484-496. ISSN 1573-4064. E-ISSN 1875-6638
Institucionální podpora: RVO:61388963
Klíčová slova: CDK inhibitors * styrylpyrazoles * Suzuki-Miyaura cross-coupling reaction * Vilsmeier-Haack reaction * CAN508 * K562
Obor OECD: Medicinal chemistry
Impakt faktor: 2.3, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.2174/1573406417666210806095710
Background: Cycle-regulating and transcriptional cyclin-dependent kinases (CDKs) are attractive targets in cancer drug development. Several CDK inhibitors have already been obtained or are close to regulatory approval for clinical applications.
Trvalý link: http://hdl.handle.net/11104/0330725
Počet záznamů: 1