Exploring the polymorphism of sofosbuvir via mechanochemistry: effect of milling jar geometry and material

0555940 - FZÚ 2023 RIV GB eng J - Článek v odborném periodiku
Chatziadi, A. - Skořepová, Eliška - Kohout, M. - Ridvan, L. - Šoóš, M.
Exploring the polymorphism of sofosbuvir via mechanochemistry: effect of milling jar geometry and material.
CrystEngComm. Roč. 24, č. 11 (2022), s. 2107-2117. ISSN 1466-8033
Institucionální podpora: RVO:68378271
Klíčová slova: polymorphism * mechanochemistry * sofosbuvir * crystal structure * powder X-ray diffraction
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.1, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1039/d1ce01561c

Mechanochemistry has been used as a green and sustainable method to explore the polymorphism of several active pharmaceutical ingredients. Until now, many experimental conditions, such as the nature and amount of liquid additive, have been investigated to understand how they affect polymorphic transformations. However, the effect of the properties of the milling jar started to be explored only recently. Here, we extend our previous studies regarding the polymorphic transformations of sofosbuvir and perform new experiments in stainless steel and polypropylene jars.
Trvalý link: http://hdl.handle.net/11104/0331182