Importing genetically altered animals: ensuring quality

0555859 - ÚMG 2024 RIV US eng J - Článek v odborném periodiku
Birling, M.C. - Fray, M. - Kašpárek, Petr - Kopkanová, Jana - Massimi, M. - Matteoni, R. - Montoliu, L. - Nutter, L.M.J. - Raspa, M. - Rozman, Jan - Ryder, E. - Scavizzi, F. - Voikar, V. - Wells, S. - Pavlovic, G. - Teboul, L.
Importing genetically altered animals: ensuring quality.
Mammalian Genome. Roč. 33, č. 1 (2022), s. 100-107. ISSN 0938-8990. E-ISSN 1432-1777
Grant CEP: GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT EF18_046/0015861
Výzkumná infrastruktura: CCP II - 90126
Institucionální podpora: RVO:68378050
Klíčová slova: cre recombinase * mouse * mice * reproducibility * expression * microbiota * rodent * cells * gene * rat
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.5, rok: 2022
Způsob publikování: Open access
https://link.springer.com/article/10.1007/s00335-021-09908-x

The reproducibility of research using laboratory animals requires reliable management of their quality, in particular of their genetics, health and environment, all of which contribute to their phenotypes. The point at which these biological materials are transferred between researchers is particularly sensitive, as it may result in a loss of integrity of the animals and/or their documentation. Here, we describe the various aspects of laboratory animal quality that should be confirmed when sharing rodent research models. We also discuss how repositories of biological materials support the scientific community to ensure the continuity of the quality of laboratory animals. Both the concept of quality and the role of repositories themselves extend to all exchanges of biological materials and all networks that support the sharing of these reagents.
Trvalý link: http://hdl.handle.net/11104/0330321