Letter to the Editor: Significant mutation enrichment in inverted repeat sites of new SARS-CoV-2 strains

0555649 - BFÚ 2022 RIV GB eng J - Článek v odborném periodiku
Bartas, M. - Goswami, Pratik - Lexa, M. - Cerven, J. - Volna, A. - Fojta, Miroslav - Brázda, Václav - Pečinka, P.
Letter to the Editor: Significant mutation enrichment in inverted repeat sites of new SARS-CoV-2 strains.
Briefings in Bioinformatics. Roč. 22, č. 5 (2021), č. článku bbab129. ISSN 1467-5463. E-ISSN 1477-4054
Grant CEP: GA ČR(CZ) GA18-15548S; GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: SARS-CoV-2 * mutations * inverted repeats
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 13.994, rok: 2021
Způsob publikování: Open access
https://academic.oup.com/bib/article/22/5/bbab129/6219140

In a recently published paper, we have found that SARS-CoV-2 hot-spot mutations are significantly associated with inverted repeat loci and CG dinucleotides. However, fast-spreading strains with new mutations (so-called mink farm mutations, England mutations and Japan mutations) have been recently described. We used the new datasets to check the positioning of mutation sites in genomes of the new SARS-CoV-2 strains. Using an open-access Palindrome analyzer tool, we found mutations in these new strains to be significantly enriched in inverted repeat loci.
Trvalý link: http://hdl.handle.net/11104/0330106