Eosinophils are dispensable for development of MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice

0555476 - ÚMG 2022 RIV NL eng J - Článek v odborném periodiku
Ruppova, K. - Lim, J.H. - Fodelianaki, G. - August, A. - Neuwirth, Aleš
Eosinophils are dispensable for development of MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice.
Immunology Letters. Roč. 239, November (2021), s. 72-76. ISSN 0165-2478. E-ISSN 1879-0542
Institucionální podpora: RVO:68378050
Klíčová slova: eae * Eosinophils * mog * Demyelination * Autoimmunity
Obor OECD: Immunology
Impakt faktor: 4.230, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0165247821001425?via%3Dihub

Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG(35-55) peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in Delta dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development.
Trvalý link: http://hdl.handle.net/11104/0329989