Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis

0555307 - BC 2022 RIV GB eng O - Ostatní výsledky
Shleeva, M. - Nikitushkin, V. - Loginov, Dmitry Sergej - Dyčka, F. - Štěrba, Ján - Demina, G. - Kaprelyants, A.
Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis.
2021. FEBS Open Bio. Wiley. Roč. 11 (2021), s. 186-186. ISSN 2211-5463. E-ISSN 2211-5463
Institucionální podpora: RVO:60077344
Klíčová slova: Mycobacterium tuberculosis * proteome * serodiagnosis
Obor OECD: Cell biology
https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095091093095091424170

Formation of dormant Mycobacterium tuberculosis (Mtb) cells is responsible for the phenomenon of latent tuberculosis. Serodiagnosis is an effective method for early detection of pathogen for many infection diseases. However, this method demonstrates low effectiveness for TB detection that could be due to incorrect antigens selected. We suggest to study the expression of protein antigens in dormant state of Mtb in vitro (5 mo old cells) obtained under gradual medium acidification which may reflect the real situation for the pathogen in case of latent TB. Analysis of the proteomic profile of active and dormant Mtb was carried out by LC­MS/MS.
Trvalý link: http://hdl.handle.net/11104/0329827