Počet záznamů: 1
Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective
- 1.0554930 - ÚMG 2022 RIV CH eng J - Článek v odborném periodiku
Krchlíková, Veronika - Hron, Tomáš - Těšický, M. - Li, T. - Hejnar, Jiří - Vinkler, M. - Elleder, Daniel
Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective.
Viruses. Roč. 13, č. 11 (2021), č. článku 2131. ISSN 1999-4915. E-ISSN 1999-4915
Grant CEP: GA ČR GA20-22063S
Institucionální podpora: RVO:68378050
Klíčová slova: avian genome * viral sensors * innate immunity * gene loss
Obor OECD: Virology
Impakt faktor: 5.818, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1999-4915/13/11/2131
Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5). Their activation establishes an antiviral state by downstream signaling that ultimately activates interferon-stimulated genes (ISGs). While in rare cases RIG-I gene loss has been detected in mammalian and avian species, most notably in the chicken, MDA5 pseudogenization has only been detected once in mammals. We have screened over a hundred publicly available avian genome sequences and describe an independent disruption of MDA5 in two unrelated avian lineages, the storks (Ciconiiformes) and the rallids (Gruiformes). The results of our RELAX analysis confirmed the absence of negative selection in the MDA5 pseudogene. In contrast to our prediction, we have shown, using multiple dN/dS-based approaches, that the MDA5 loss does not appear to have resulted in any compensatory evolution in the RIG-I gene, which may partially share its ligand-binding specificity. Together, our results indicate that the MDA5 pseudogenization may have important functional effects on immune responsiveness in these two avian clades.
Trvalý link: http://hdl.handle.net/11104/0329549
Počet záznamů: 1