Počet záznamů: 1  

The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

  1. 1.
    0554522 - ÚMG 2022 RIV GB eng J - Článek v odborném periodiku
    Cassioli, C. - Onnis, A. - Finetti, F. - Capitani, N. - Brunetti, J. - Compeer, E. - Niederlová, Veronika - Štěpánek, Ondřej - Dustin, M. - Baldari, C.
    The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly.
    Journal of Cell Science. Roč. 134, č. 16 (2021), č. článku jcs258462. ISSN 0021-9533. E-ISSN 1477-9137
    Grant CEP: GA ČR GJ19-03435Y
    Institucionální podpora: RVO:68378050
    Klíčová slova: Immune synapse * Primary cilium * Bardet-Biedl syndrome * Centrosome * Proteasome * Dynein
    Obor OECD: Cell biology
    Impakt faktor: 5.235, rok: 2021
    Způsob publikování: Omezený přístup
    https://journals.biologists.com/jcs/article/134/16/jcs258462/271909/The-Bardet-Biedl-syndrome-complex-component-BBS1

    Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here, we investigated the potential role of Bardet-Biedl syndrome 1 protein (BBS1), an essential core component of the BBS complex that cooperates with the IFT system in ciliary protein trafficking, in the assembly of the T cell synapse. We demonstrated that BBS1 allows for centrosome polarization towards the immune synapse. This function is achieved through the clearance of centrosomal F-actin and its positive regulator WASH1 (also known as WASHC1), a process that we demonstrated to be dependent on the proteasome. We show that BBS1 regulates this process by coupling the 19S proteasome regulatory subunit to the microtubule motor dynein for its transport to the centrosome. Our data identify the ciliopathy-related protein BBS1 as a new player in T cell synapse assembly that functions upstream of the IFT system to set the stage for polarized vesicular trafficking and sustained signaling.
    Trvalý link: http://hdl.handle.net/11104/0329233

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.