Tick salivary gland transcriptomics and proteomics

0554304 - BC 2022 RIV GB eng J - Článek v odborném periodiku
Martins, Larissa Almeida - Bensaoud, Chaima - Kotál, Jan - Chmelař, J. - Kotsyfakis, Michalis
Tick salivary gland transcriptomics and proteomics.
Parasite immunology. Roč. 43, č. 5 (2021), č. článku e12807. ISSN 0141-9838. E-ISSN 1365-3024
Grant CEP: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759
Institucionální podpora: RVO:60077344
Klíčová slova: serine proteinase-inhibitors * histamine-binding proteins * rna * sialome * insight * vector * acari * sialotranscriptome * identification * micrornas * proteome * salivary gland * sialome * tick * transcriptome
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.206, rok: 2021
Způsob publikování: Omezený přístup
https://onlinelibrary.wiley.com/doi/10.1111/pim.12807

'Omics' technologies have facilitated the identification of hundreds to thousands of tick molecules that mediate tick feeding and play a role in the transmission of tick-borne diseases. Deep sequencing methodologies have played a key role in this knowledge accumulation, profoundly facilitating the study of the biology of disease vectors lacking reference genomes. For example, the nucleotide sequences of the entire set of tick salivary effectors, the so-called tick 'sialome', now contain at least one order of magnitude more transcript sequences compared to similar projects based on Sanger sequencing. Tick feeding is a complex and dynamic process, and while the dynamic 'sialome' is thought to mediate tick feeding success, exactly how transcriptome dynamics relate to tick-host-pathogen interactions is still largely unknown. The identification and, importantly, the functional analysis of the tick 'sialome' is expected to shed light on this 'black box'. This information will be crucial for developing strategies to block pathogen transmission, not only for anti-tick vaccine development but also the discovery and development of new, pharmacologically active compounds for human diseases.
Trvalý link: http://hdl.handle.net/11104/0328938