Počet záznamů: 1
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
- 1.0554292 - ÚMG 2022 RIV DE eng J - Článek v odborném periodiku
Adamowicz, M. - Hailstone, R. - Demin, A.A. - Komulainen, E. - Hanzlíková, Hana - Brazina, J. - Gautam, A. - Wells, S. - Caldecott, Keith
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.
Nature Cell Biology. Roč. 23, č. 12 (2021), s. 1287-1298. ISSN 1465-7392. E-ISSN 1476-4679
Institucionální podpora: RVO:68378050
Klíčová slova: rna-polymerase-ii * single-strand breaks * histone h2b ubiquitylation * poly(adp-ribose) polymerase * adp-ribosylation * dependent monoubiquitylation * chromatin-structure * cellular-response * terminal domain * human homolog
Obor OECD: Cell biology
Impakt faktor: 28.213, rok: 2021
Způsob publikování: Open access
https://www.nature.com/articles/s41556-021-00792-w
Adamowicz et al. report that toxic PARP1 activity, induced by ataxia-associated mutations in XRCC1, impairs the recovery of global transcription during DNA base excision repair by promoting aberrant recruitment and activity of the histone ubiquitin protease USP3.
Trvalý link: http://hdl.handle.net/11104/0328927
Počet záznamů: 1