Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus

0554206 - BC 2022 RIV DE eng J - Článek v odborném periodiku
Kozelková, Tereza - Doležel, David - Grunclová, Lenka - Kučera, Matěj - Perner, Jan - Kopáček, Petr
Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus.
Ticks and Tick-borne Diseases. Roč. 12, č. 4 (2021), č. článku 101694. ISSN 1877-959X. E-ISSN 1877-9603
Grant CEP: GA ČR(CZ) GA18-01832S; GA MŠMT(CZ) EF16_019/0000759
Institucionální podpora: RVO:60077344
Klíčová slova: rhipicephalus boophilus microplus * blood * synganglion * receptors * localization * metabolism * expression * proteins * insights * target * Tick * Ixodes ricinus * Insulin receptor * akt * tor * RNA interference
Obor OECD: Parasitology
Impakt faktor: 3.817, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S1877959X21000479?via%3Dihub

Ticks are blood-feeding arachnids transmitting a variety of pathogens to humans and animals. A unique trait in tick physiology is their ability to engorge and digest large amounts of host blood, ensuring their high reproductive potential. Activation of the blood digestive machinery in the tick gut, as well as processes controlling maturation of ovaries, are triggered upon blood meal uptake by still largely unknown mechanisms. Sensing of the nutritional status in metazoan organisms is facilitated by the evolutionarily conserved Insulin Signaling Pathway (ISP) and the interlinked Target of Rapamycin (TOR) pathway. Recently, we have identified three components of these pathways in the hard tick Ixodes ricinus midgut transcriptome, namely a putative insulin receptor (InR), and the downstream intracellular serine/threonine kinases AKT and TOR.
Trvalý link: http://hdl.handle.net/11104/0328824