Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

0554089 - BC 2022 RIV GB eng J - Článek v odborném periodiku
Chavez, A. - Wang, X. - Marnin, L. - Archer, N. - Hammond, H.L. - Carroll, E. - Shaw, D.K. - Tully, B. - Buskirk, A. - Ford, S. - Butler, L. - Shahi, P. - Morozova, K. - Clement, C. - Lawres, L. - Neal, A. - Mamoun, C. - Mason, K. - Hobbs, B. - Scoles, G.A. - Barry, E. - Sonenshine, D.E. - Pal, U. - Valenzuela, J. G. - Sztein, M. - Pasetti, M.F. - Levin, M. - Kotsyfakis, Michalis - Jay, S. - Huntley, J. W. … celkem 33 autorů
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection.
Nature Communications. Roč. 12, č. 1 (2021), č. článku 3696. E-ISSN 2041-1723
Institucionální podpora: RVO:60077344
Klíčová slova: epidermal t-cells * gamma-delta * salivary-glands * borrelia-burgdorferi * ixodes-scapularis * immune-response * virus-infection * protein * identification * exosomes
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 17.694, rok: 2021
Způsob publikování: Open access
https://www.nature.com/articles/s41467-021-23900-8

Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases. Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.
Trvalý link: http://hdl.handle.net/11104/0328731