Phosphonium amphiphilic carbosilane dendrons as nanocarriers for drug delivery.

0553685 - ÚCHP 2022 CZ eng A - Abstrakt
Edr, Antonín - Apartsin, J. - Červenková Šťastná, Lucie - Krupková, Alena - Cuřínová, Petra - Strašák, Tomáš
Phosphonium amphiphilic carbosilane dendrons as nanocarriers for drug delivery.
Book of abstracts. 2021.
[Conference Advances in Organic, Bioorganic and Pharmaceutical Chemistry "LIBLICE 2021" /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA20-21421S
GRANT EU: European Commission(XE) CA17140 - COST Action
Institucionální podpora: RVO:67985858
Klíčová slova: phosphonium dendrons * amphiphilic dendrons, * drug delivery
Obor OECD: Organic chemistry

Herein, we report a newly synthesized series of amphiphilic carbosilane dendrons bearing phosphonium groups on the periphery (Fig. 1). The series consists of six substrates with varying number of hydrophobic tails, tail lengths and number of hydrophilic dendritic wedges (Fig. 2). We have studied their supramolecular behaviour in aqueous media and drug loading efficiencies. Thanks to their cationic character, these substrates can be potentially used for the delivery of low-molecular and macromolecular bioactive cargo into cells.
Trvalý link: http://hdl.handle.net/11104/0328431