Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

0553682 - ÚCHP 2023 RIV CH eng J - Článek v odborném periodiku
Edr, Antonín - Wróbel, D. - Krupková, Alena - Červenková Šťastná, Lucie - Cuřínová, Petra - Novák, A. - Malý, J. - Kalasová, J. - Malý, M. - Strašák, Tomáš
Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.
International Journal of Molecular Sciences. Roč. 23, č. 4 (2022), č. článku 2114. E-ISSN 1422-0067
Grant CEP: GA MŠMT(CZ) LTC19049
GRANT EU: European Commission(XE) CA17140 - COST Action
Institucionální podpora: RVO:67985858
Klíčová slova: carbosilane * dendrons * amphiphiles
Obor OECD: Organic chemistry
Impakt faktor: 5.6, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/23/4/2114

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp‐CS‐DDNs) capable of self‐assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp‐CS‐DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp‐CS‐DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.
Trvalý link: http://hdl.handle.net/11104/0328427