5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-D]pyrimidines for treatment of lymphoma

0553599 - ÚEB 2022 RIV eng P - Patentový dokument
Havlíček, Libor - Šturc, Antonín - Řezníčková, Eva - Jorda, Radek - Kryštof, Vladimír - Strnad, Miroslav
5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-D]pyrimidines for treatment of lymphoma.
2021. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Datum udělení patentu: 06.10.2021. Číslo patentu: EP3749670
Institucionální podpora: RVO:61389030
Klíčová slova: apoptosis * cyclin-depedent kinases * inhibitors
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/patent/search?q=pn%3DEP3749670B1

5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.
Trvalý link: http://hdl.handle.net/11104/0328357