Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

0553496 - MBÚ 2023 RIV GB eng J - Článek v odborném periodiku
Horvat, M. - Weilch, V. - Rädisch, Robert - Hecko, S. - Schiefer, A. - Rudroff, F. - Wilding, B. - Klempier, N. - Pátek, Miroslav - Martínková, Ludmila - Winkler, M.
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime.
Catalysis Science &Technology. Roč. 12, č. 1 (2022), s. 62-66. ISSN 2044-4753. E-ISSN 2044-4761
Grant CEP: GA ČR(CZ) GF20-23532L
Institucionální podpora: RVO:61388971
Klíčová slova: nitrile synthesis * carboxylic acid reductase * aldoxime dehydratase * chemoenzymatic cascade
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 5, rok: 2022
Způsob publikování: Open access
https://pubs.rsc.org/en/content/articlelanding/2022/CY/D1CY01694F

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.
Trvalý link: http://hdl.handle.net/11104/0330484