Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering

0553277 - ÚEM 2022 RIV CH eng J - Článek v odborném periodiku
Nirwan, V.P. - Filová, Eva - Al-Kattan, A. - Kabashin, A.V. - Fahmi, A.
Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering.
Nanomaterials. Roč. 11, č. 2 (2021), č. článku 519. E-ISSN 2079-4991
Grant CEP: GA MŠMT(CZ) LO1508
Institucionální podpora: RVO:68378041
Klíčová slova: electrospinning * pulsed laser ablation in liquids * nanofibers * polycaprolactone (PCL) * TiN nanoparticles * theranostics * biocompatibility * scaffold for tissue engineering
Obor OECD: Biomaterials (as related to medical implants, devices, sensors)
Impakt faktor: 5.719, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2079-4991/11/2/519

Herein, we report the fabrication and characterization of novel polycaprolactone (PCL)-based nanofibers functionalized with bare (ligand-free) titanium nitride (TiN) nanoparticles (NPs) for tissue engineering applications. Nanofibers were prepared by a newly developed protocol based on the electrospinning of PCL solutions together with TiN NPs synthesized by femtosecond laser ablation in acetone. The generated hybrid nanofibers were characterised using spectroscopy, microscopy, and thermal analysis techniques. As shown by scanning electron microscopy measurements, the fabricated electrospun nanofibers had uniform morphology, while their diameter varied between 0.403 +/- 0.230 mu m and 1.1 +/- 0.15 mu m by optimising electrospinning solutions and parameters. Thermal analysis measurements demonstrated that the inclusion of TiN NPs in nanofibers led to slight variation in mass degradation initiation and phase change behaviour (T-m). In vitro viability tests using the incubation of 3T3 fibroblast cells in a nanofiber-based matrix did not reveal any adverse effects, confirming the biocompatibility of hybrid nanofiber structures. The generated hybrid nanofibers functionalized with plasmonic TiN NPs are promising for the development of smart scaffold for tissue engineering platforms and open up new avenues for theranostic applications.
Trvalý link: http://hdl.handle.net/11104/0328260