Počet záznamů: 1  

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

  1. 1.
    0552871 - ÚEM 2022 RIV GB eng J - Článek v odborném periodiku
    Yang, S. - Gigout, S. - Molinaro, A. - Naito-Matsui, Y. - Hilton, S. - Foscarin, S. - Nieuwenhuis, B. - Tan, L.CH. - Verhaagen, J. - Pizzorusso, T. - Saksida, L.M. - Bussey, T.M. - Kitagawa, H. - Kwok, Jessica - Fawcett, James
    Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
    Molecular Psychiatry. Roč. 26, č. 10 (2021), s. 5658-5668. ISSN 1359-4184. E-ISSN 1476-5578
    Grant CEP: GA ČR(CZ) GA19-10365S; GA MŠMT(CZ) EF15_003/0000419
    Institucionální podpora: RVO:68378041
    Klíčová slova: brain extracellular-matrix * perineuronal nets * recognition memory * neural plasticity * restores memory * sulfate
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 13.437, rok: 2021
    Způsob publikování: Open access
    https://www.nature.com/articles/s41380-021-01208-9

    Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
    Trvalý link: http://hdl.handle.net/11104/0327962

     
     
Počet záznamů: 1  

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