On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer's Disease

0552836 - ÚEM 2022 RIV CH eng J - Článek v odborném periodiku
Kriška, Ján - Heřmanová, Zuzana - Knotek, Tomáš - Turečková, Jana - Anděrová, Miroslava
On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer's Disease.
International Journal of Molecular Sciences. Roč. 22, č. 18 (2021), č. článku 9689. E-ISSN 1422-0067
Grant CEP: GA ČR(CZ) GA21-24674S
Institucionální podpora: RVO:68378041
Klíčová slova: Alzheimer's disease * Wnt signaling * amyloid beta * central nervous system * dementia * ischemic brain injury * neurodegeneration * stroke
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 6.208, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/22/18/9689

Ischemic brain injury and Alzheimer's disease (AD) both lead to cell death in the central nervous system (CNS) and thus negatively affect particularly the elderly population. Due to the lack of a definitive cure for brain ischemia and AD, it is advisable to carefully study, compare, and contrast the mechanisms that trigger, and are involved in, both neuropathologies. A deeper understanding of these mechanisms may help ameliorate, or even prevent, the destructive effects of neurodegenerative disorders. In this review, we deal with ischemic damage and AD, with the main emphasis on the common properties of these CNS disorders. Importantly, we discuss the Wnt signaling pathway as a significant factor in the cell fate determination and cell survival in the diseased adult CNS. Finally, we summarize the interesting findings that may improve or complement the current sparse and insufficient treatments for brain ischemia and AD, and we delineate prospective directions in regenerative medicine.
Trvalý link: http://hdl.handle.net/11104/0327930