Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

0552048 - ÚEM 2022 RIV DE eng J - Článek v odborném periodiku
Corradi, Ch. - Gentiluomo, M. - Gajdán, L. - Cavestro, G.M. - Kreivenaite, E. - Di Franco, G. - Sperti, C. - Giaccherini, M. - Petrone, M.Ch. - Tavano, F. - Gioffreda, D. - Morelli, L. - Souček, P. - Andriulli, A. - Izbicki, J.R. - Napoli, N. - Malecka-Panas, E. - Hegyi, P. - Neoptolemos, J. - Landi, S. - Vashist, Y. - Pasquali, C. - Lu, Y. - Červená, Klára - Theodoropoulos, G.E. - Moz, S. - Capurso, G. - Strobel, O. - Carrara, S. - Hackert, T. - Hlaváč, V. - Archibugi, L. - Oliverius, M. - Vanella, G. - Vodička, Pavel - Arcidiacono, P.G. - Pezzilli, R. - Milanetto, A.C. - Lawlor, R.T. - Ivanauskas, A. - Szentesi, A. - Kupcinskas, J. - Testoni, S.G.G. - Loveček, M. - Nentwich, M. - Gazouli, M. - Luchini, C. - Zuppardo, R.A. - Darvasi, E. - Brenner, H. - Gheorghe, C. - Jamroziak, K. - Canzian, F. - Campa, D.
Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility.
International Journal of Cancer. Roč. 148, č. 11 (2021), s. 2779-2788. ISSN 0020-7136. E-ISSN 1097-0215
Institucionální podpora: RVO:68378041
Klíčová slova: association study * long noncoding RNA * pancreatic cancer * single nucleotide polymorphism
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 7.316, rok: 2021
Způsob publikování: Open access
https://onlinelibrary.wiley.com/doi/10.1002/ijc.33475

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 x 10(-9)). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
Trvalý link: http://hdl.handle.net/11104/0327946