Novel marine secondary metabolites worthy of development as anticancer agents: A review

0551687 - BC 2022 RIV CH eng J - Článek v odborném periodiku
Mbaoji, F.N. - Nweze, Justus Amuche - Yang, L. - Huang, Y. - Huang, S. - Onwuka, A.M. - Peter, I.E. - Mbaoji, C.Ch. - Jiang, M. - Zhang, Y. - Pan, L. - Yang, D.
Novel marine secondary metabolites worthy of development as anticancer agents: A review.
BASELOCT 2021: MDPI, 2021. Molecules. Roč. 26, č. 19 (2021), č. článku 5769. E-ISSN 1420-3049
Institucionální podpora: RVO:60077344
Klíčová slova: cancer * marine secondary metabolites * lead optimization * cancer cell line * drug development
Obor OECD: Microbiology
Impakt faktor: 4.927, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1420-3049/26/19/5769

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.
Trvalý link: http://hdl.handle.net/11104/0326974