Hybrid organometallic galectin inhibitors.

0551681 - ÚCHP 2022 eng A3 - Přednáška/prezentace nepublikovaná
Hamala, Vojtěch - Kurfiřt, Martin - Karban, Jindřich
Hybrid organometallic galectin inhibitors.
[INNOGLY-ECI-WG3-2021: Young Glyco-Scientists on stage symposium, 27.09.2021]
Způsob prezentace: Prezentace
Institucionální podpora: RVO:67985858
Klíčová slova: organometallic compounds * glycomymetics * galectin inhibitors
Obor OECD: Organic chemistry

In this project, I focus on replacing planar aromatic substituents in known galectin inhibitors with arene-like or arene-containing organometallic structure – ferrocenes3, ruthenium arenes4 and ruthenium tetrazenes,5 which all possess known antitumor or antimetastatic properties. This creates hybrid molecules that can act both as galectin inhibitors and cytotoxic and/or antimetastatic agents. The electroactivity of the attached organometallic component also allows to detect interaction of the hybrid molecules with their biological targets.
Trvalý link: http://hdl.handle.net/11104/0326917