Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes

0551384 - FZÚ 2022 RIV CH eng J - Článek v odborném periodiku
Angelova, A. - Angelov, Borislav - Drechsler, M. - Bizien, T. - Gorshkova, Yu. E. - Deng, Y.
Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes.
Frontiers in Cell and Developmental Biology. Roč. 9, FEB (2021), č. článku 617984. ISSN 2296-634X. E-ISSN 2296-634X
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Výzkumná infrastruktura: ELI Beamlines III - 90141
Institucionální podpora: RVO:68378271
Klíčová slova: docosapentaenoyl phospholipids * lipid cubic phase * inverted hexagonal phase * plasmalogen-loaded cubosomes * hexosomes * SAXS * cryo-TEM
Obor OECD: Polymer science
Impakt faktor: 6.081, rok: 2021
Způsob publikování: Open access

Structural properties of plasmenyl-glycerophospholipids (plasmalogens) have been scarcely studied for plasmalogens with long polyunsaturated fatty acid (PUFA) chains, despite of their significance for the organization and functions of the cellular membranes. Elaboration of supramolecular assemblies involving PUFA-chain plasmalogens in nanostructured mixtures with lyotropic lipids may accelerate the development of nanomedicines for certain severe pathologies (e.g., peroxisomal disorders, cardiometabolic impairments, and neurodegenerative Alzheimer's and Parkinson's diseases). Here, we investigate the spontaneous self-assembly of bioinspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM).
Trvalý link: http://hdl.handle.net/11104/0326800