DeutEx

0550855 - MBÚ 2022 RIV CZ eng L4 - Software
Kavan, Daniel - Kádek, Alan - Kruppa, G. H. - Man, Petr
DeutEx.
Interní kód: DeutEx ; 2021
Technické parametry: Samostatný program sestavený v jazyce java fungující na běžných výpočetních strojích pod systémy Unix/Linux, Windows a MAC OC
Ekonomické parametry: Zvýšení prostupnosti analýz a snazší interpretace dat v HDX-MS analýzách.
Grant CEP: GA ČR(CZ) GA19-16084S; GA ČR(CZ) GA16-24309S; GA ČR(CZ) GA16-20860S; GA ČR(CZ) GF16-34818L; GA ČR GAP206/12/0503; GA MŠMT(CZ) LD15089
Institucionální podpora: RVO:61388971
Klíčová slova: Java application * mass spectrometric data * hydrogen/deuterium exchange
Obor OECD: Biochemical research methods
www.deutex.org

Anotace v jazyce práceDeutEx is a Java-based standalone application enabling fully automated processing of mass spectrometric data from hydrogen/deuterium exchange experiments. It has three main interfaces where user can perform 1) peptide mapping – assembly of the main input file for subsequent calculations, 2) manage the data and organize them according to experimental conditions, 3) run the calculation, fully review and export the resulting data. The program needs LCMS data exported in text files and can be thus compatible with a majority of MS instrumentation. The output is either graphical (uptake plots) or simple text files organized according to the community guidelines or compatible with a web-based application MSTools. The program calculates percentage of deuteration, number of exchanged deuterons, signal intensity and peak-width. It can manage numerous experimental conditions, replicates and different protein sequences. It can handle any protein modification and mutations.

Trvalý link: http://hdl.handle.net/11104/0326683