CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD

0549896 - MBÚ 2022 RIV US eng J - Článek v odborném periodiku
Černý, Ondřej - Godlee, C. - Tocci, R. - Cross, N. E. - Shi, H. - Williamson, J. C. - Alix, E. - Lehner, P. J. - Holden, D. W.
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
PLoS Pathogens. Roč. 17, č. 7 (2021), č. článku e1009771. ISSN 1553-7366. E-ISSN 1553-7374
Institucionální podpora: RVO:61388971
Klíčová slova: expression * receptor * adhesion * activation * polyubiquitination * ubiquitination * cytoskeleton * subsets * cloning
Obor OECD: Microbiology
Impakt faktor: 7.464, rok: 2021
Způsob publikování: Open access
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009771

Author summary Salmonella enterica is the causative agent of very large numbers of serious and life-threatening diseases in humans and livestock throughout the world. Clearance of S. enterica from the host is dependent on T cell-mediated immune responses. We show here that the Salmonella SPI-2 type III secretion system effector SteD inhibits activation of T cells by reducing contacts between infected antigen-presenting cells and T cells. This is mediated by degradation of an adhesion G protein-coupled receptor CD97. Our work reveals that CD97 stabilizes the interaction between antigen-presenting cells and T cells and identifies this process as a direct target for bacterial pathogens.
Trvalý link: http://hdl.handle.net/11104/0325786