Chalcones: Synthetic chemistry follows where nature leads

0549577 - ÚEB 2022 RIV CH eng J - Článek v odborném periodiku
Jasim, H. A. - Nahar, Lutfun - Jasim, M. A. - Moore, S. - Ritchie, K. J. - Sarker, S. D.
Chalcones: Synthetic chemistry follows where nature leads.
Biomolecules. Roč. 11, č. 8 (2021), č. článku 1203. E-ISSN 2218-273X
Institucionální podpora: RVO:61389030
Klíčová slova: Anticancer * Antimicrobial * Bioactivities * Biomolecular interactions * Chalcones * Mechanisms * Natural products * Phenolics * Synthesis
Obor OECD: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Impakt faktor: 6.064, rok: 2021
Způsob publikování: Open access
http://doi.org/10.3390/biom11081203

Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti‐inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring chalcones, and their unique chemical structural features inspired the synthesis of numerous chalcone derivatives. In fact, structural features of chalcones are easy to construct from simple aromatic compounds, and it is convenient to perform structural modifications to generate functionalized chalcone derivatives. Many of these synthetic analogs were shown to possess similar bioactivities as their natural counterparts, but often with an enhanced potency and reduced toxicity. This review article aims to demonstrate how bioinspired synthesis of chalcone derivatives can potentially introduce a new chemical space for exploitation for new drug discovery, justifying the title of this article. However, the focus remains on critical appraisal of synthesized chalcones and their derivatives for their bioactivities, linking to their interactions at the biomolecular level where appropriate, and revealing their possible mechanisms of action.
Trvalý link: http://hdl.handle.net/11104/0325587