Počet záznamů: 1  

Development in the Mammalian Auditory System Depends on Transcription Factors

  1. 1.
    0549276 - BTÚ 2022 RIV CH eng J - Článek v odborném periodiku
    Elliott, K. L. - Pavlínková, Gabriela - Chizhikov, V. V. - Yamoah, E. N. - Fritzsch, B.
    Development in the Mammalian Auditory System Depends on Transcription Factors.
    International Journal of Molecular Sciences. Roč. 22, č. 8 (2021), č. článku 4189. E-ISSN 1422-0067
    Grant CEP: GA ČR(CZ) GA20-06927S
    Institucionální podpora: RVO:86652036
    Klíčová slova: transcription factors * neuronal differentiation * bHLH genes
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 6.208, rok: 2021
    Způsob publikování: Open access
    https://www.mdpi.com/1422-0067/22/8/4189

    We review the molecular basis of several transcription factors (Eya1, Sox2), including the three related genes coding basic helix-loop-helix (bHLH, see abbreviations) proteins (Neurog1, Neurod1, Atoh1) during the development of spiral ganglia, cochlear nuclei, and cochlear hair cells. Neuronal development requires Neurog1, followed by its downstream target Neurod1, to cross-regulate Atoh1 expression. In contrast, hair cells and cochlear nuclei critically depend on Atoh1 and require Neurod1 expression for interactions with Atoh1. Upregulation of Atoh1 following Neurod1 loss changes some vestibular neurons' fate into hair cells, highlighting the significant interplay between the bHLH genes. Further work showed that replacing Atoh1 by Neurog1 rescues some hair cells from complete absence observed in Atoh1 null mutants, suggesting that bHLH genes can partially replace one another. The inhibition of Atoh1 by Neurod1 is essential for proper neuronal cell fate, and in the absence of Neurod1, Atoh1 is upregulated, resulting in the formation of intraganglionic HCs. Additional genes, such as Eya1/Six1, Sox2, Pax2, Gata3, Fgfr2b, Foxg1, and Lmx1a/b, play a role in the auditory system. Finally, both Lmx1a and Lmx1b genes are essential for the cochlear organ of Corti, spiral ganglion neuron, and cochlear nuclei formation. We integrate the mammalian auditory system development to provide comprehensive insights beyond the limited perception driven by singular investigations of cochlear neurons, cochlear hair cells, and cochlear nuclei. A detailed analysis of gene expression is needed to understand better how upstream regulators facilitate gene interactions and mammalian auditory system development.
    Trvalý link: http://hdl.handle.net/11104/0325306

     
     
Počet záznamů: 1  

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