Počet záznamů: 1  

Functional specialization within the exo70 gene family in arabidopsis

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    0549042 - ÚEB 2022 RIV CH eng J - Článek v odborném periodiku
    Marković, Vedrana - Kulich, I. - Žárský, Viktor
    Functional specialization within the exo70 gene family in arabidopsis.
    International Journal of Molecular Sciences. Roč. 22, č. 14 (2021), č. článku 7595. E-ISSN 1422-0067
    Grant CEP: GA MŠMT(CZ) EF16_019/0000738; GA MŠMT(CZ) LM2015062
    Institucionální podpora: RVO:61389030
    Klíčová slova: exocyst complex * EXO70 * Arabidopsis
    Obor OECD: Cell biology
    Impakt faktor: 6.208, rok: 2021
    Způsob publikování: Open access
    http://doi.org/10.3390/ijms22147595

    Localized delivery of plasma-membrane and cell-wall components is a crucial process for plant cell growth. One of the regulators of secretory-vesicle targeting is the exocyst tethering complex. The exocyst mediates first interaction between transport vesicles and the target membrane before their fusion is performed by SNARE proteins. In land plants, genes encoding the EXO70 exocyst subunit underwent an extreme proliferation with 23 paralogs present in the Arabidopsis (Arabidopsis thaliana) genome. These paralogs often acquired specialized functions during evolution. Here, we analyzed functional divergence of selected EXO70 paralogs in Arabidopsis. Performing a systematic cross-complementation analysis of exo70a1 and exo70b1 mutants, we found that EXO70A1 was functionally substituted only by its closest paralog, EXO70A2. In contrast, none of the EXO70 isoforms tested were able to substitute EXO70B1, including its closest relative, EXO70B2, pointing to a unique function of this isoform. The presented results document a high degree of functional specialization within the EXO70 gene family in land plants.
    Trvalý link: http://hdl.handle.net/11104/0325081

     
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