Nanokompozitnyj sloj na osnove kollagenovych nanovolokon i sposob jego izgotovlenija

0548194 - ÚSMH 2022 RIV rus P - Patentový dokument
Suchý, Tomáš - Šupová, Monika - Denk, František - Rýglová, Šárka - Žaloudková, Margit - Sucharda, Zbyněk - Ballay, R. - Horný, L. - Čejka, Z. - Pokorný, M. - Knotková, K. - Velebný, V.
Nanokompozitnyj sloj na osnove kollagenovych nanovolokon i sposob jego izgotovlenija.
[Nano-composite layer based on collagen nano-fibers and its production method.]
2021. Vlastník: Ústav struktury a mechaniky hornin AV ČR, v. v. i. - České vysoké učení technické v Praze - ProSpon spol. s.r.o. - Contipro a.s. Datum udělení patentu: 28.09.2021. Číslo patentu: RU2756164
Grant CEP: GA TA ČR(CZ) TA04010330
Institucionální podpora: RVO:67985891
Klíčová slova: Collagen * Layer * Composite * Nanofiber * Electrospining
Obor OECD: Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
https://patents.s3.yandex.net/RU2756164C2_20210928.pdf

Predmetom izobretěnija javljajetsja bioaktivnyj nanokompozitnyj sloj, polučennyj kombinacijej elektrospinninga i elektroobduva rastvora kollagena, soděržaščego nanočasticy gidroksiapatita i poli (etilenoksid), gdě posle polučenija i sšivanija sloj sostojit iz 75-100 mas. % volokon kollagena I tipa, 5-15 mas. % gidroksiapatita i 0-1 mas. % polietilenoksida. Predmetom nastojaščego izobretěnija tože javljajetsja sposob polučenija ukazannogo sloja i sposob děponirovanija antibiotikov dlja boleje effektivnogo ich vysvobožděnija bez uveličenija citotoksičnosti. Ukazannyj sposob vključajet propitku sšitych stěrilizovannych slojev kollagena/gidroksiapatita antibiotikami v forme rastvora. Predmet izobretěnija takže vključajet ortopedičeskije i děntalnyje implantaty na osnove metalla ili metalličeskich splavov, elektrostatičeski pokrytyje ukazannym kompozitnym slojem na osnove kollagenovych nanovolokon s intěgrirovannymi nanočasticami gidroksiapatita i antibiotikom ili kombinacijej antibiotikov.

The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.
Trvalý link: http://hdl.handle.net/11104/0324534