An Outbreak of Trichophyton quinckeanum Zoonotic Infections in the Czech Republic Transmitted from Cats and Dogs

0548006 - MBÚ 2022 RIV CH eng J - Článek v odborném periodiku
Lysková, P. - Dobiáš, R. - Čmoková, Adéla - Kolařík, Miroslav - Hamal, P. - Šmatlaková, K. - Hušek, J. - Mencl, K. - Mallátová, N. - Poláčková, Z. - Krnáčová, A. - Palkovičová, K. - Jablonská, D. - Macháčová, J. - Drlik, Z. - Bázsoová, D. - Jaworská, P. - Svobodová, L. - Hubka, Vít
An Outbreak of Trichophyton quinckeanum Zoonotic Infections in the Czech Republic Transmitted from Cats and Dogs.
Journal of Fungi. Roč. 7, č. 9 (2021), č. článku 684. E-ISSN 2309-608X
Grant CEP: GA MZd(CZ) NU21-05-00681
Institucionální podpora: RVO:61388971
Klíčová slova: zoophilic dermatophytes * tinea capitis * tinea corporis * antifungal susceptibility testing * eucast * terbinafine * zoonotic infections * MALDI-TOF mass spectrometry
Obor OECD: Microbiology
Impakt faktor: 5.724, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2309-608X/7/9/684

Trichophyton quinckeanum, a zoophilic dermatophyte mostly known as the causative agent of rodent favus, is relatively rarely reported to cause human infections. Indeed, no infections were detected in Czechia between 2012 and 2015 despite routine verification of species identification by ITS rDNA sequencing. By contrast, 25 human and 11 animal cases of infection were documented from December 2016 to December 2020 and the rates tended to grow every following year. Interestingly, most of the cases were reported in the Olomouc region, suggesting a local outbreak. We bring the evidence that human T. quinckeanum infections are most commonly contracted from infected cats or, less frequently, dogs. Although rodents or contaminated soil and environment could be the source of infection to cats and dogs, the occurrence of infections in multiple animals in the same household suggests direct transmission among animals. Confirmation of the identification by molecular methods is highly recommended due to morphological similarity with T. mentagrophytes/T. interdigitale. Antifungal susceptibility testing of isolates to eight antifungals was performed using EUCAST methodology (E.Def 11.0). Among the tested antifungals, terbinafine, amorolfine, ciclopirox and efinaconazole were most potent in vitro and elevated minimum inhibitory concentrations were obtained for fluconazole and ketoconazole.
Trvalý link: http://hdl.handle.net/11104/0326024