Počet záznamů: 1  

Soybean (Glycine max) is able to absorb, metabolize and accumulate fenbendazole in all organs including beans

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    0547995 - ÚEB 2022 RIV CH eng J - Článek v odborném periodiku
    Podlipná, Radka - Navrátilová, M. - Raisová Stuchlíková, L. - Moťková, Kateřina - Langhansová, Lenka - Skálová, L. - Szotáková, B.
    Soybean (Glycine max) is able to absorb, metabolize and accumulate fenbendazole in all organs including beans.
    International Journal of Molecular Sciences. Roč. 22, č. 13 (2021), č. článku 6647. E-ISSN 1422-0067
    Grant CEP: GA ČR(CZ) GA18-08452S; GA MŠMT(CZ) EF16_019/0000738
    Institucionální podpora: RVO:61389030
    Klíčová slova: Anthelmintics * Antioxidant enzymes * Benzimidazoles * Biotransformation * Isoflavonoids * Pharmaceuticals
    Obor OECD: Pharmacology and pharmacy
    Impakt faktor: 6.208, rok: 2021
    Způsob publikování: Open access
    http://doi.org/10.3390/ijms22136647

    Although manure is an important source of minerals and organic compounds it represents a certain risk of spreading the veterinary drugs in the farmland and their permeation to human food. We tested the uptake of the anthelmintic drug fenbendazole (FBZ) by soybean, a common crop plant, from the soil and its biotransformation and accumulation in different soybean organs, including beans. Soybeans were cultivated in vitro or grown in a greenhouse in pots. FBZ was extensively metabolized in roots of in vitro seedlings, where sixteen metabolites were identified, and less in leaves, where only two metabolites were found. The soybeans in greenhouse absorbed FBZ by roots and translocated it to the leaves, pods, and beans. In roots, leaves, and pods two metabolites were identified. In beans, FBZ and one metabolite was found. FBZ exposure did not affect the plant fitness or yield, but reduced activities of some antioxidant enzymes and isoflavonoids content in the beans. In conclusion, manure or biosolids containing FBZ and its metabolites represent a significant risk of these pharmaceuticals entering food consumed by humans or animal feed. In addition, the presence of these drugs in plants can affect plant metabolism, including the production of isoflavonoids.
    Trvalý link: http://hdl.handle.net/11104/0324131

     
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Počet záznamů: 1  

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