Incidence of congenital anomalies in children born after assisted reproduction in the Czech Republic

0547262 - ÚI 2022 GB eng A - Abstrakt
Šípek, A. - Gregor, V. - Klaschka, Jan - Malý, Marek - Šípek jr., A.
Incidence of congenital anomalies in children born after assisted reproduction in the Czech Republic.
International Journal of Epidemiology. Roč. 50, Suppl. 1 (2021), s. 219-220. ISSN 0300-5771. E-ISSN 1464-3685
Institucionální podpora: RVO:67985807

Background: The number of children conceived by assisted reproduction techniques (ART) is increasing in the Czech Republic. However, several studies reported increased incidence of congenital anomalies in ART conceived children. The main goal of this study was to evaluate this theoretical risk using population-based data from Czech medial registries. Methods: The retrospective epidemiological analysis was performed using data from the National Registry of Congenital Anomalies and National Registry of Newborns, run by the Institute of Health Information and Statistics of the Czech Republic. All diagnoses of congenital anomalies (Q00-Q99) were included. We compared the incidences of congenital anomalies in naturally conceived children and ART conceived children born in the Czech Republic during 5 years period (2013-2017). Statistical analysis was performed by Fisher's exact test. Results: During the selected period there were 547 675 children born in the Czech Republic (531 064 were naturally conceived children and 16 611 were ART conceived children). The incidence of congenital anomalies was 3.90% in naturally conceived children group and 4.35% in ART conceived children. This difference is statistically significant (p = 0.003). Conclusions: In our population-based study, we confirmed a significantly higher general incidence of congenital anomalies in ART conceived children. Key messages: The general incidence of congenital anomalies in ART conceived children is higher (compared to the incidence of congenital anomalies in naturally conceived children). Possible causes of this phenomenon shall be further analysed.
Trvalý link: http://hdl.handle.net/11104/0323539