Autoimmune phenomena and spontaneous tumour regression. The role of carbonic anhydrase I

0547072 - MBÚ 2022 RIV US eng J - Článek v odborném periodiku
Minichová, L. - Škultéty, L'udovít - Lakota, J.
Autoimmune phenomena and spontaneous tumour regression. The role of carbonic anhydrase I.
Journal of Cellular and Molecular Medicine. Roč. 25, č. 11 (2021), s. 5339-5340. ISSN 1582-1838. E-ISSN 1582-4934
Institucionální podpora: RVO:61388971
Klíčová slova: stem-cell transplantation * aplastic-anemia * autoantibodies * malignancy
Obor OECD: Oncology
Impakt faktor: 5.295, rok: 2021
Způsob publikování: Open access
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16525

We have observed the spontaneous tumour regression in four patients (breast cancer, Hodgkin's disease, non-Hodgkin's lymphoma and Ewing's sarcoma) who had relapsed/progressed after high-dose chemotherapy (HDC) and autologous haematopoietic stem cell transplantation (ASCT).1 Patients' blood counts strongly resembled the blood counts in aplastic anaemia (aplastic anaemia (AA)-like syndrome). Moreover, some of these patients' morphology of the bone marrow trephine biopsies was identical to the AA picture. It should be noted that in some patients who were treated by conventional chemotherapy only, a similar phenomenon has been observed, too (Lakota J, unpublished observation). In a provoking paper,2 the authors proposed that the autoimmune (anti-tumour) activity against present malignancy also operates against haematopoietic stem cells. The final clinical and laboratory pattern in these patients is present as acquired aplastic anaemia (AA). This pathophysiological mechanism could explain pancytopenia, which frequently occurs in patients with haematological as well as non-haematological malignancies. The conclusion would be that pancytopenia which is present in AA or AA-like syndrome reflects an ongoing immune reaction against underlying malignancy.
Trvalý link: http://hdl.handle.net/11104/0323415