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Chalepin and chalepensin: Occurrence, biosynthesis and therapeutic potential
- 1.0546752 - ÚEB 2022 RIV CH eng J - Článek v odborném periodiku
Nahar, Lutfun - Al-Majmaie, S. - Al-Groshi, A. - Rasul, A. - Sarker, S. D.
Chalepin and chalepensin: Occurrence, biosynthesis and therapeutic potential.
Molecules. Roč. 26, č. 6 (2021), č. článku 1609. E-ISSN 1420-3049
Institucionální podpora: RVO:61389030
Klíčová slova: Bioactivity * Biosynthesis * Chalepensin * Chalepin * Ruta chalepensis * Rutaceae
Obor OECD: Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions (pharmacogenomics, gene-based therapeutics)
Impakt faktor: 4.927, rok: 2021
Způsob publikování: Open access
http://doi.org/10.3390/molecules26061609
Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.
Trvalý link: http://hdl.handle.net/11104/0323142
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