Počet záznamů: 1
New perspective on the geographic distribution and evolution of lymphocytic choriomeningitis virus, Central Europe
- 1.0546062 - ÚBO 2022 RIV US eng J - Článek v odborném periodiku
Fornůsková, Alena - Hiadlovská, Zuzana - Macholán, Miloš - Piálek, Jaroslav - Goüy de Bellocq, Joëlle
New perspective on the geographic distribution and evolution of lymphocytic choriomeningitis virus, Central Europe.
Emerging Infectious Diseases. Roč. 27, č. 10 (2021), s. 2638-2647. ISSN 1080-6040. E-ISSN 1080-6059
Grant CEP: GA ČR(CZ) GA16-20049S; GA ČR(CZ) GA16-23773S
Grant ostatní: AV ČR(CZ) MSM200931901
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Výzkumná infrastruktura: e-INFRA CZ - 90140
Institucionální podpora: RVO:68081766 ; RVO:67985904
Klíčová slova: mouse Mus musculus * murine cytomegalovirus * syrian hamsters * infection * origin * diversity * strains * rodents * genome
Obor OECD: Veterinary science; Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology (UZFG-Y)
Impakt faktor: 16.126, rok: 2021
Způsob publikování: Open access
https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis, in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specifi city because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic-Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.
Trvalý link: http://hdl.handle.net/11104/0322659
Počet záznamů: 1