Direct comparison of analogous amphiphilic gradient and block polyoxazolines

0545562 - ÚMCH 2022 RIV US eng J - Článek v odborném periodiku
Loukotová, Lenka - Švec, Pavel - Groborz, Ondřej - Heizer, T. - Beneš, Hynek - Raabová, Helena - Bělinová, T. - Herynek, V. - Hrubý, Martin
Direct comparison of analogous amphiphilic gradient and block polyoxazolines.
Macromolecules. Roč. 54, č. 17 (2021), s. 8182-8194. ISSN 0024-9297. E-ISSN 1520-5835
Grant CEP: GA ČR(CZ) GA19-01602S; GA MŠMT(CZ) LTC19032; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF16_013/0001775
Grant ostatní: AV ČR(CZ) FWO-19-03
Program: Bilaterální spolupráce
Výzkumná infrastruktura: Czech-BioImaging - 90062; Czech-BioImaging II - 90129
Institucionální podpora: RVO:61389013 ; RVO:68378050
Klíčová slova: poly-2-phenyl-2-oxazoline * gradient polymer * polymerization kinetics
Obor OECD: Polymer science; Biochemistry and molecular biology (UMG-J)
Impakt faktor: 6.057, rok: 2021
Způsob publikování: Omezený přístup
https://pubs.acs.org/doi/10.1021/acs.macromol.0c02674

Both gradient and block copolymers can be used as drug delivery systems, but their relative (dis)advantages remain unknown. Thus, we directly compared analogous amphiphilic gradient and block polyoxazolines for their physicochemical properties and potential as building components of nanodrugs. For this purpose, we prepared a library of 18 polymers with varying ratios of monomeric units, using 2-methyl-2-oxazoline (MeOx) as a hydrophilic monomer and 2-phenyl-2-oxazoline (PhOx), 2-(4-butylphenyl)-2-oxazoline (BuPhOx), or 2-(4-butoxyphenyl)-2-oxazoline (BuOPhOx) as a hydrophobic monomer, and determined their homo/heteropolymerization kinetics. Our results showed that gradient copolymers had broader glass transition intervals and formed nanoparticles several times smaller and more compact than the corresponding block analogs. In particular, PMeOx70-grad-PhOx30 and PMeOx70-grad-BuPhOx30 exhibited a significantly higher drug loading capacity and entrapment efficiency than their corresponding block analogs. Notwithstanding these differences, all polymers were cyto- and hemocompatible in vitro. Therefore, analogous gradient and block copolymers may be alternatively used for specific biomedical applications.
Trvalý link: http://hdl.handle.net/11104/0322846