Controlled anchoring of (phenylureido)sulfonamide-based receptor moieties: an impact of binding site multiplication on complexation properties

0545524 - ÚCHP 2022 RIV CH eng J - Článek v odborném periodiku
Salvadori, Karolína - Krupková, Alena - Červenková Šťastná, Lucie - Müllerová, Monika - Eigner, V. - Strašák, Tomáš - Cuřínová, Petra
Controlled anchoring of (phenylureido)sulfonamide-based receptor moieties: an impact of binding site multiplication on complexation properties.
Molecules. Roč. 26, č. 18 (2021), č. článku 5670. E-ISSN 1420-3049
Grant CEP: GA ČR(CZ) GA20-07833S
Institucionální podpora: RVO:67985858
Klíčová slova: host-guest chemistry * dendrimers * supramolecular chemistry
Obor OECD: Organic chemistry
Impakt faktor: 4.927, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1420-3049/26/18/5670

The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and 1H-NMR in classical or competitive titration mode, the attachment to a carrier allocates the active moieties to mutual positions predetermining the function of the whole receptor molecule. Bivalent receptors form self-aggregates. Dendritic receptors with low dihydrogen phosphate loadings offer a
cooperative complexation mode associated with a positive dendritic effect. In higher dihydrogen phosphate concentrations, the dendritic branches act independently and the binding mode changes to 1:1 anion: complexation site. Despite the anchoring, the dendritic receptors retain the superior efficiency and selectivity of a monomer, paving the way to recyclable receptors, desirable for economic and ecological reasons.
Trvalý link: http://hdl.handle.net/11104/0323701