Longitudinal evidence for immunosenescence and inflammaging in free-living great tits

0545282 - ÚBO 2022 RIV US eng J - Článek v odborném periodiku
Těšický, M. - Krajzingrová, T. - Świderská, Z. - Syslová, K. - Bílková, B. - Eliáš, J. - Velová, H. - Svobodová, J. - Bauerová, P. - Albrecht, Tomáš - Vinkler, M.
Longitudinal evidence for immunosenescence and inflammaging in free-living great tits.
Experimental Gerontology. Roč. 154, October (2021), č. článku 111527. ISSN 0531-5565. E-ISSN 1873-6815
Grant CEP: GA ČR GA15-11782S
Institucionální podpora: RVO:68081766
Klíčová slova: Aging * Ageing * Birds * Ecoimmunology * Haematology * Immunosenescence * Innate immunity senescence * Inflammation * Respiratory burst * Oxidative burst * Oxidative damage * Oxidative stress * Passerines * Redox balance * Avian inflammaging * Testosterone * Wild
Obor OECD: Ornithology
Impakt faktor: 4.253, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub

The first-line effector mechanisms of immune defence, including inflammation and oxidative burst, contribute significantly to host-pathogen resistance. Whether these immune responses undergo age-related changes in birds remains unknown. Here, we tracked selected inflammatory parameters in 54 free-living great tits (Parus major) of known age, captured repeatedly over three consecutive years, with the aims to investigate long-term repeatability and age-dependent changes in cellular oxidative burst responsiveness upon in vitro stimulation with bacterial lipopolysaccharide (LPS), and to identify its relationships with leukotriene B4 (LTB4) levels and haematological traits. In addition, we linked these immunological traits to selected physiological markers (antioxidants and oxidative stress markers). LTB4 levels increased with age and we have shown a similar non-significant tendency also for absolute granulocyte counts, indicating propagating chronic inflammation over the bird's lifetime, consistent with the inflammaging hypothesis. In contrast, cellular oxidative burst followed a quadratic trend of dependency on age with a peak in midlife individuals, in line with the immunosenescence hypothesis. Interestingly, LTB4 levels were positively associated with general oxidative damage, but negatively with antioxidant glutathione peroxidase activity, indicating links to redox balance. This longitudinal study demonstrates the contrasting patterns of age-related changes in background and acute markers of pro-inflammatory immunity contributing to immunosenescence in birds and thus provides basis for interpretation of the tested inflammatory markers in cross-cohort datasets.
Trvalý link: http://hdl.handle.net/11104/0322017


Vědecká data: Dryad